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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Treg17 cells ： ウィキペディア英語版 Treg17 cells Helper T cells are essential part of body's immune system. These cells are divided in many subsets based upon their ability to produce different cytokines. Following the discovery of interleukin-17 (IL-17) producing T helper (Th17) cells as a distinct lineage of T helper cells it became clear that these cells play an important role in the host defense and participate in the pathogenesis of many inflammatory and autoimmune diseases. The Th17 cells can alter their differentiation program ultimately giving rise to either protective or pro-inflammatory pathogenic cells. The protective and non-pathogenic Th17 cells are termed as Treg17 cells.〔Singh B, Schwartz JA, Sandrock C, Bellemore SM, Nikoopour E. 2013. Modulation of autoimmune diseases by interleukin (IL)-17 producing regulatory T helper (Th17) cells. Indian J Med Res. 138:591-4. PMID 24434314〕 == Activation == Like conventional regulatory T cells (Treg), induction of regulatory Treg17 cells could play an important role in modulating and preventing certain autoimmune diseases. Treg17 (Regulatory Th17) cells are generated from CD4+ T cells. Treg17 cells with regulatory phenotype with in vivo immune-suppressive properties in the gut have also been identified as rTh17 cells.〔Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, O'Connor W Jr, Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC, Flavell RA. Control of TH17 cells occurs in the small intestine. Nature. 2011; 475:514-8. doi: 10.1038/nature10228. PMID 21765430〕 Similar to Th17 cells the Treg17 development depended on the transcription factor Stat3.〔Chaudhry A, Rudra D, Treuting P, Samstein RM, Liang Y, Kas A, Rudensky AY. CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science. 2009;326:986-91. doi 10.1126/science.1172702. PMID 19797626〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Treg17 cells」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.